Substrate: Discs, large homolog 1 (Cell junction protein)
Seq-ID: P31007 [Drosophila melanogaster]
Download:fasta csv
Interaction Network(s):
External Source(s): Phosida
MINT Interaction(s):
MINT-1772955   LAP4_DROME
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
epidermal growth factor receptor binding,
structural molecule activity,
guanylate kinase activity,
signal transducer activity		 neuromuscular junction,
basolateral plasma membrane,
septate junction,
cytoskeleton,
terminal button,
apical cortex,
postsynaptic membrane		 establishment or maintenance of polarity of larval imaginal disc epithelium,
zonula adherens assembly,
morphogenesis of a polarized epithelium,
negative regulation of cell proliferation,
basal protein localization,
male courtship behavior,
peripheral nervous system development,
establishment or maintenance of epithelial cell apical/basal polarity,
locomotor rhythm,
establishment or maintenance of polarity of follicular epithelium,
synaptic transmission,
cell adhesion,
septate junction assembly,
establishment or maintenance of neuroblast polarity,
positive phototaxis,
asymmetric protein localization involved in cell fate determination,
dorsal closure,
cell proliferation,
establishment of spindle orientation,
neuron differentiation,
central nervous system development,
establishment or maintenance of polarity of embryonic epithelium,
regulation of border follicle cell delamination,
regulation of cell cycle
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 496 AVPPGTPRAVSTEDITREPRT - 18327897
HTP
0.16
 - -
0.79
 - medium
S 496 AVPPGTPRAVSTEDITREPRT - 18327897
HTP
0.16
 - -
0.79
 - medium
T 714 AANNNLDKQSTLDRKKKNFTF - 18327897
HTP
0.22
 - -
0.52
 - medium
T 714 AANNNLDKQSTLDRKKKNFTF - 18327897
HTP
0.22
 - -
0.52
 - medium

Substrate: Discs, large homolog 1 (Cell junction protein)
Seq-ID: Q12959 [Homo sapiens]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-48506   M3K3_HUMAN
MINT-68489   LCK_HUMAN
MINT-68490   KCNA3_HUMAN
MINT-72835   TOPK_HUMAN
MINT-73083   AT2B4_HUMAN
MINT-1901801   ADA17_HUMAN
MINT-7145813   ASAP1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein C-terminus binding,
potassium channel regulator activity,
protein kinase binding,
cytoskeletal protein binding,
phosphoprotein phosphatase activity,
phosphatase binding,
guanylate kinase activity		 sarcolemma,
cell-cell junction,
basolateral plasma membrane,
cytosol,
endoplasmic reticulum membrane,
postsynaptic membrane,
postsynaptic density		 cortical actin cytoskeleton organization,
mitotic cell cycle G1/S transition checkpoint,
endothelial cell proliferation,
establishment or maintenance of cell polarity,
actin filament organization,
interspecies interaction between organisms,
negative regulation of mitotic cell cycle,
cell-cell adhesion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 110 SLSPSVEKYRYQDEDTPPQEH - 18669648
HTP
0.86
 - MAGUK_N_PEST
0.74
 - low
T 115 VEKYRYQDEDTPPQEHISPQI - 18669648
HTP
0.39
 - MAGUK_N_PEST
0.75
 - low
S 122 DEDTPPQEHISPQITNEVIGP - 18669648
HTP
0.35
 - MAGUK_N_PEST
0.74
 - low
S 232 YEEITLERGNSGLGFSIAGGT CaM-KII_group 12933808
LTP
1.00
 - PDZ
0.41
 - low
S 567 IHDLREQMMNSSISSGSGSLR - 18669648
HTP
0.86
 - -
0.53
 - low
S 571 REQMMNSSISSGSGSLRTSQK - 18669648
HTP
1.00
 - -
0.58
 - low
S 575 MNSSISSGSGSLRTSQKRSLY - 18669648
HTP
0.94
 - -
0.48
 - low
S 619 FGDILHVINASDDEWWQARQV - 18220336
HTP
0.81
 - SH3
0.31
 - low
S 684 MGSKGLKHVTSNASDSESSYR - 15302935
HTP
0.55
 - -
0.68
 - low
S 684 MGSKGLKHVTSNASDSESSYR - 18669648
HTP
0.55
 - -
0.68
 - low
S 687 KGLKHVTSNASDSESSYRGQE - 15302935
HTP
0.55
 - -
0.63
 - low
S 687 KGLKHVTSNASDSESSYRGQE - 17081983
HTP
0.55
 - -
0.63
 - low
S 687 KGLKHVTSNASDSESSYRGQE - 18669648
HTP
0.55
 - -
0.63
 - low
Y 760 KRDYEVDGRDYHFVTSREQME - 18083107
HTP
0.92
 - GuKc
0.51
 - low

Substrate: Discs, large homolog 1 (Cell junction protein)
Seq-ID: Q12959-2 [Homo sapiens]
Download:fasta csv
Interaction Network(s):
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-73072   AT2B2_HUMAN
MINT-7212195   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein C-terminus binding,
potassium channel regulator activity,
protein kinase binding,
cytoskeletal protein binding,
phosphoprotein phosphatase activity,
phosphatase binding,
guanylate kinase activity		 sarcolemma,
cell-cell junction,
basolateral plasma membrane,
cytosol,
endoplasmic reticulum membrane,
postsynaptic membrane,
postsynaptic density		 cortical actin cytoskeleton organization,
mitotic cell cycle G1/S transition checkpoint,
endothelial cell proliferation,
establishment or maintenance of cell polarity,
actin filament organization,
interspecies interaction between organisms,
negative regulation of mitotic cell cycle,
cell-cell adhesion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 619 FGDILHVINASDDEWWQARQV - 18220336
HTP
0.90
 - SH3
0.31
 - medium

Substrate: Discs, large homolog 1 (Cell junction protein)
Seq-ID: Q811D0 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-50216   NMDZ1_MOUSE
MINT-3091786   NRCAM_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein complex scaffold,
protein kinase binding,
phosphatase binding		 cell projection membrane,
neuromuscular junction,
basolateral plasma membrane,
lateral plasma membrane,
immunological synapse,
endoplasmic reticulum membrane,
postsynaptic membrane,
membrane raft,
postsynaptic density,
cell-cell adherens junction		 branching involved in ureteric bud morphogenesis,
cortical actin cytoskeleton organization,
positive regulation of developmental growth,
amyloid precursor protein metabolic process,
formation of immunological synapse,
activation of protein kinase activity,
endothelial cell proliferation,
hard palate development,
smooth muscle tissue development,
T cell cytokine production,
actin filament organization,
membrane raft organization,
regulation of membrane potential,
positive regulation of actin filament polymerization,
positive regulation of multicellular organism growth,
peristalsis,
negative regulation of mitotic cell cycle,
cell-cell adhesion,
reproductive structure development,
protein localization,
lens development in camera-type eye,
positive regulation of cell proliferation,
negative regulation of T cell proliferation,
T cell activation,
embryonic skeletal system morphogenesis,
negative regulation of epithelial cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 301 KAVEALKEAGSIVRLYVKRRK - 16452087
HTP
0.66
 - PDZ
0.26
 --
T 684 DMGSKGLKHVTSNASDSESSY - 17242355
HTP
0.69
 - -
0.68
 --

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